Cytoplasmic retention signal
WebApr 8, 2014 · When present within 4-residues of the TMD it serves as a Golgi export signal, but when located at the C-terminus of the 68-residue p14 cytoplasmic endodomain it functions as an ER retention signal. The PBM has no effect on protein trafficking when located at an internal position in the cytoplasmic domain. WebNov 12, 2004 · Here we report that the cytoplasmic localization of hHDAC6 is resistant to treatment with leptomycin B (LMB), demonstrate that the SE14 repeat domain is responsible for this resistance, and show that hHDAC6 possesses intrinsic …
Cytoplasmic retention signal
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WebMar 30, 2024 · The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers. Mary K. Ernst Laboratory of Molecular ... suggesting that it may perform the same function in cells when the activating signal is no longer present. Structurally, the human I κ Bα molecule can be divided ... WebApr 1, 2006 · Wnt signalling, β-Catenin, Nucleo-cytoplasmic shuttling, FRAP Introduction The canonical Wnt signalling pathway is highly conserved throughout the animal kingdom and regulates crucial steps in cell fate decisions, …
WebAug 1, 1999 · studies provide evidence for a cytoplasmic targeting/retention signal (CTRS) in MA that is responsible for intracytoplasmic capsid assembly in Type D retroviruses. WebMar 14, 2024 · The retention signal is recognized by specific receptors present in the ER and cis-GA, which retrieve the protein from post-ER compartments and return them to …
WebJun 20, 2000 · The IRF3 protein has a nuclear export signal (NES) specifying its cytoplasmic retention . Examination of the p48 protein primary amino acid sequence … WebJan 21, 2024 · Misfolded and/or unassembled secretory and membrane proteins in the endoplasmic reticulum (ER) may be retro-translocated into the cytoplasm, where they undergo ER-associated degradation, or ERAD. The mechanisms by which misfolded proteins are recognized and degraded through this pathway have been studied …
Webcdc25C is a phosphatase, which activates the mitosis-promoting factor cyclin B1/cdc2 by dephosphorylation, and thus triggers G2/M transition. The activity of cdc25C itself is controlled by phosphoryl
WebAug 1, 1997 · Although JNK is located in both the cytoplasm and the nucleus of quiescent cells, activation of JNK is associated with accumulation of JNK in the nucleus ( 8 ). … headwaters stateWebJan 9, 1998 · The retrieval signal was found to be functional even when placed at the distal end of the wild-type SIV Env protein with 164 amino acids in the cytoplasmic tail, as shown by the lack of proteolytic processing and lack of … headwaters solarWebSignal-Based Retention of Golgi Resident Proteins via Carboxy-Terminal Lysine-Based Motifs The glycosylation of proteins and lipids depends on nucleotide-sugar conjugates that are translocated from the cytoplasm into the lumen of the ER or Golgi via multispanning membrane proteins called nucleotide-sugar transporters (NSTs) ( Berninsone and ... headwaters state bank presque isle wisconsinWebMar 1, 2004 · Cytoplasmic retention of signal transducers prevails when cells are poised to receive an extracellular signal, and nuclear … headwaters staffWebThe N- terminal signal/anchor of cytochrome P450 2C1 functioned as an ER retention signal when placed at the N terminus of several reporter proteins but not when fused at the C terminus of the extracellular domain of epidermal growth factor receptor, with or without a heterologous cytoplasmic domain. headwaters spaWebNov 30, 2007 · However, cytoplasmic reaccumulation after ligand removal, although rapid for GFP-Stat3α (t ½ = 15 min), was markedly delayed for GFP-Stat3β (t ½ > 180 min). Prolonged nuclear retention of Stat3β was accompanied by reduced intranuclear mobility and increased immobile fraction. golf car batteries at walmartWebIntracytoplasmic protein targeting in mammalian cells is critical for organelle function as well as virus assembly, but the signals that mediate it are poorly defined. We show here that … headwaters state forest