WebMTT assay was used to assess the effect of FTH1 overexpression on cell proliferation. Data were normalized by those in parent cells without FAC supplementation. Data were expressed as mean ± SD ... WebOct 7, 2024 · In addition to cytosolic ferritin, the overexpression of mitochondrial ferritin (FTMT) in neuronal cells inhibits erastin-induced ferroptosis and increases the cellular labile iron pool ( Wang et al., 2016 ).

Iron derived from autophagy-mediated ferritin degradation ... - eLife

WebIn vitro, overexpression of FTH1 reduced cell growth and migration, which were not reduced by iron supplementation. Furthermore, cells were subcutaneously inoculated into the nude mice. Results showed FTH1 overexpression decreased tumor growth in the absence of iron supplementation but not in the presence of iron supplementation. … WebMay 9, 2024 · First, since FTH1 degradation is an important mechanism in TetC-induced breast cancer cell death, whether FTH1 overexpression alters TetC cytotoxity in breast cancer cells deserves further study. Second, the cell lines need to be used in mice to determine whether TetC can inhibit tumor growth through ferroptosis. himba tribe pics

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WebBACKGROUND: An emerging MRI reporter, ferritin heavy chain (FTH1), is recently applied to enhance the contrast and increase the sensitivity of MRI in the monitoring of solid tumors. However, FTH1-overexpression-related cytotoxicity is required to be explored. WebSep 21, 2024 · Overexpression of FTH1 in PC-12 cells impaired ferritinophagy and downregulated microtubule-associated protein light chain 3 and nuclear receptor … WebTFRC, FTH1, POLD1, E2F1, and c‐Myc were decreased, whereas CC3 and Axin2 were increased and TNKS was not changed in MC38 shTFRC cells (Figure 5C; and Figure S6A, Supporting Information). Furthermore, E2F1 overexpression rescued TFRC knockdown mediated POLD1 reduction and CC3 activation (Figure S6B, Supporting Information). To … home improvement in underwear