NettetIntegrin β1 regulates proliferation, apoptosis, and migration of trophoblasts through activation of phosphoinositide 3 kinase/protein kinase B signaling Integrin β1 regulates … Nettet1. mai 2004 · Integrins not only promote adhesion to the extracellular matrix (ECM), but provide anchor points for the cytoskeleton and mediate signalling events through a …
Targeting Ferroptosis Attenuates Interstitial Inflammation and …
Nettet11. apr. 2024 · Among them, tru04080 neuroactive ligand-receptor interaction, tru00260 glycine, serine, and threonine metabolism, tru04514 cell adhesion molecules, tru04512 extracellular matrix-receptor interaction, and tru00330 arginine and proline metabolism were significantly upregulated, and tru04350 TGF-beta signaling pathway, tru00561 … NettetThe integrin α6β4 activates Src to inhibit ferroptosis. (A) Vector control and β4-depleted cells were assessed for phosphorylated (Y418) Src by immunoblotting 3 h after ECM detachment. Relative... new zealand christmas trees
Frontiers Ferroptosis and Cancer: Complex Relationship and …
Nettet1. des. 2024 · Ferroptosis is unique among the different cell death modalities, as it has been mostly linked to pathophysiological conditions and because several metabolic ... A recent study further proposed that GPX4 mRNA expression is positively regulated by α6β4 integrin (Brown et al., 2024), albeit the underlying mechanism remains to be ... NettetIn contrast, ECM detachment of cells lacking α6β4 is sufficient to trigger ferroptosis because GPX4 is suppressed. This causal link between α6β4 and ferroptosis has implications for cancer biology and therapy. The α6β4 integrin promotes resistance to ferroptosis Caitlin W. Brown, John J. Amante, Hira Lal Goel, and Arthur M. Mercurio Nettet4. des. 2024 · The integrin α6β4 represses ACSL4 to inhibit ferroptosis. Expression of ACSL4 was assessed by qPCR (A) and immunoblotting (B) in vector control and β4-depleted cells after 2 h of ECM detachment. new zealand citizen by birth