Webto1 may also modulate the maximal AP upstroke velocity (dV/dt max). However, data on the effects of to1 on the AP I upstroke are lacking. Presently, various knock-out mouse … WebFrequency- and voltage-dependent effects of a class I antiarrhythmic agent (nicainoprol) on the maximal upstroke velocity ( max) of the action potential of guinea-pig papillary muscle are compared with the effects predicted by a kinetic model of frequency- and voltage-dependent block of fast sodium channels.

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Web(17) Maximum upstroke velocity of Ca-action potentials recorded in partially depolarized ventricles were enhanced by phenylephrine, and the enhancement was eliminated by sotalol but not by phentolamine. (18) This frequency-dependent maximum upstroke velocity block increased at higher stimulation frequencies and at higher drug concentrations. WebAP amplitude, AP duration at 90% repolarization (APD 90 ) ( Figure 1 H and 1I) as well as maximal upstroke velocity (dV/dt max ) ( Figure S2B) were similar at all conditions. netflix tv series stranger things

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WebAbstract. We studied the relation of the maximal upstroke velocity (Vmax) of action potentials to the peak sodium current (INa) under voltage clamp in single, internally … Web(17) Maximum upstroke velocity of Ca-action potentials recorded in partially depolarized ventricles were enhanced by phenylephrine, and the enhancement was eliminated by … Web1 sep. 1999 · The drug depressed maximal upstroke velocity in a use-dependent manner; the IC50 value was near 150 μM in muscles driven at 1 Hz, 60 μM at 3 Hz, 38 μM at 5 Hz, and 3 μM at 1 Hz in muscles depolarized with 14 mM K+. Submicromolar terodiline frequently had a small positive inotropic effect, ... netflix tv series the defeated